Cloned (Comment) | Organism |
---|---|
into the pVL1393 vector | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
Y348F | mutant | Homo sapiens |
Y348F/Y504F | mutant | Homo sapiens |
Y504F | mutant | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
aspirin | - |
Homo sapiens | |
nimesulide | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0021 | - |
arachidonic acid | wild-type, cyclooxygenase activity | Homo sapiens | |
0.0034 | - |
arachidonic acid | mutant Y348F/Y504F, cyclooxygenase activity | Homo sapiens | |
0.0038 | - |
arachidonic acid | mutant Y348F, cyclooxygenase activity | Homo sapiens | |
0.0042 | - |
arachidonic acid | mutant Y504F, cyclooxygenase activity | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
73000 | - |
determined by SDS-PAGE and immunoblotting | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + AH2 + O2 | Homo sapiens | - |
prostaglandin H2 + A + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0027 | - |
mutant Y348F, cyclooxygenase activity | Homo sapiens |
0.0039 | - |
mutant Y504F, cyclooxygenase activity | Homo sapiens |
0.0047 | - |
mutant Y348F/Y504F, cyclooxygenase activity | Homo sapiens |
0.0058 | - |
wild-type, cyclooxygenase activity | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + AH2 + O2 | - |
Homo sapiens | prostaglandin H2 + A + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
hPGHS-2 | - |
Homo sapiens |
PGHS | - |
Homo sapiens |
PGHS-2 | - |
Homo sapiens |
prostaglandin H synthase | - |
Homo sapiens |
prostaglandin H synthase-2 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
lipoxygenase activity assay at room temperature | Homo sapiens |
30 | - |
cyclooxygenase activity assay | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
lipoxygenase activity assay | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00027 | - |
nimesulide | mutant Y348F/Y504F, cyclooxygenase inhibition | Homo sapiens | |
0.0009 | - |
nimesulide | mutant Y504F, cyclooxygenase inhibition | Homo sapiens | |
0.001 | - |
nimesulide | wild-type, cyclooxygenase inhibition | Homo sapiens |